Role of activated natural killer cells in oral diseases.
Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383Role of activated natural killer cells in oral diseases.
Auteurs : Yuji Kamoda [Japon] ; Hiroshi Uematsu ; Akihiro Yoshihara ; Hideo Miyazaki ; Hidenobu SenpukuSource :
- Japanese journal of infectious diseases [ 1344-6304 ] ; 2008.
Descripteurs français
- KwdFr :
- Antigènes CD (métabolisme), Antigènes de différenciation des lymphocytes T (métabolisme), Caries dentaires (immunologie), Caries dentaires (microbiologie), Cellules tueuses naturelles (cytologie), Cellules tueuses naturelles (immunologie), Femelle (MeSH), Humains (MeSH), Infections bactériennes (immunologie), Infections bactériennes (microbiologie), Infections opportunistes (immunologie), Infections opportunistes (microbiologie), Lactobacillus (isolement et purification), Lectines de type C (MeSH), Maladies parodontales (immunologie), Maladies parodontales (microbiologie), Mâle (MeSH), Salive (microbiologie), Streptococcus (isolement et purification), Sujet âgé (MeSH).
- MESH :
- cytologie : Cellules tueuses naturelles.
- immunologie : Caries dentaires, Cellules tueuses naturelles, Infections bactériennes, Infections opportunistes, Maladies parodontales.
- isolement et purification : Lactobacillus, Streptococcus.
- microbiologie : Caries dentaires, Infections bactériennes, Infections opportunistes, Maladies parodontales, Salive.
- métabolisme : Antigènes CD, Antigènes de différenciation des lymphocytes T.
- Femelle, Humains, Lectines de type C, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Aged (MeSH), Antigens, CD (metabolism), Antigens, Differentiation, T-Lymphocyte (metabolism), Bacterial Infections (immunology), Bacterial Infections (microbiology), Dental Caries (immunology), Dental Caries (microbiology), Female (MeSH), Humans (MeSH), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Lactobacillus (isolation & purification), Lectins, C-Type (MeSH), Male (MeSH), Opportunistic Infections (immunology), Opportunistic Infections (microbiology), Periodontal Diseases (immunology), Periodontal Diseases (microbiology), Saliva (microbiology), Streptococcus (isolation & purification).
- MESH :
- chemical , metabolism : Antigens, CD, Antigens, Differentiation, T-Lymphocyte.
- cytology : Killer Cells, Natural.
- immunology : Bacterial Infections, Dental Caries, Killer Cells, Natural, Opportunistic Infections, Periodontal Diseases.
- isolation & purification : Lactobacillus, Streptococcus.
- microbiology : Bacterial Infections, Dental Caries, Opportunistic Infections, Periodontal Diseases, Saliva.
- Aged, Female, Humans, Lectins, C-Type, Male.
Abstract
Many of the protective immune responses of old people are impaired and this leads to an increased risk of oral bacterial infections. Little is known about the interaction between the systemic immune response on one hand and oral infections and oral diseases on the other. Here, we conducted an epidemiological study of the independent elderly to determine the relationships between activated natural killer (NK) cells and oral bacterial infections: oral diseases such as dental caries and periodontal disease. One hundred independent elderly people aged 77 years old (53 males, 47 females) were examined. Blood samples were drawn, and activated NK cells were evaluated using CD16, CD56, and CD69 monoclonal antibodies with flow cytometry. Bacterial counts for oral streptococci, lactobacillus, and opportunistic pathogens were performed using culture techniques. Oral disease examinations were performed by dentists. A larger percentage of CD69(+)NK cells (CD16(+)CD56(+)) showed significant correlations to the isolation numbers of total streptococci (r=0.409, P<0.01), the species numbers of opportunistic pathogens (r=-0.318, P<0.01), the numbers of decayed teeth (r=-0.223, P<0.05), and the amount of bridge work (r=0.219, P<0.05). A higher proportion of CD69(+)NK cells is associated with the incidence of dental caries and the number of opportunistic pathogens and total streptococci in the oral cavity of the elderly. This suggests that the proportionate number of CD69(+)NK cells may be a useful indicator for oral infection in elderly subjects.
PubMed: 19050357
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of activated natural killer cells in oral diseases.</title><author><name sortKey="Kamoda, Yuji" sort="Kamoda, Yuji" uniqKey="Kamoda Y" first="Yuji" last="Kamoda">Yuji Kamoda</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gerodontology, Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gerodontology, Tokyo Medical and Dental University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Uematsu, Hiroshi" sort="Uematsu, Hiroshi" uniqKey="Uematsu H" first="Hiroshi" last="Uematsu">Hiroshi Uematsu</name></author><author><name sortKey="Yoshihara, Akihiro" sort="Yoshihara, Akihiro" uniqKey="Yoshihara A" first="Akihiro" last="Yoshihara">Akihiro Yoshihara</name></author><author><name sortKey="Miyazaki, Hideo" sort="Miyazaki, Hideo" uniqKey="Miyazaki H" first="Hideo" last="Miyazaki">Hideo Miyazaki</name></author><author><name sortKey="Senpuku, Hidenobu" sort="Senpuku, Hidenobu" uniqKey="Senpuku H" first="Hidenobu" last="Senpuku">Hidenobu Senpuku</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:19050357</idno><idno type="pmid">19050357</idno><idno type="wicri:Area/Main/Corpus">000374</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000374</idno><idno type="wicri:Area/Main/Curation">000374</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000374</idno><idno type="wicri:Area/Main/Exploration">000374</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of activated natural killer cells in oral diseases.</title><author><name sortKey="Kamoda, Yuji" sort="Kamoda, Yuji" uniqKey="Kamoda Y" first="Yuji" last="Kamoda">Yuji Kamoda</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gerodontology, Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gerodontology, Tokyo Medical and Dental University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Uematsu, Hiroshi" sort="Uematsu, Hiroshi" uniqKey="Uematsu H" first="Hiroshi" last="Uematsu">Hiroshi Uematsu</name></author><author><name sortKey="Yoshihara, Akihiro" sort="Yoshihara, Akihiro" uniqKey="Yoshihara A" first="Akihiro" last="Yoshihara">Akihiro Yoshihara</name></author><author><name sortKey="Miyazaki, Hideo" sort="Miyazaki, Hideo" uniqKey="Miyazaki H" first="Hideo" last="Miyazaki">Hideo Miyazaki</name></author><author><name sortKey="Senpuku, Hidenobu" sort="Senpuku, Hidenobu" uniqKey="Senpuku H" first="Hidenobu" last="Senpuku">Hidenobu Senpuku</name></author></analytic><series><title level="j">Japanese journal of infectious diseases</title><idno type="ISSN">1344-6304</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Antigens, CD (metabolism)</term><term>Antigens, Differentiation, T-Lymphocyte (metabolism)</term><term>Bacterial Infections (immunology)</term><term>Bacterial Infections (microbiology)</term><term>Dental Caries (immunology)</term><term>Dental Caries (microbiology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Killer Cells, Natural (cytology)</term><term>Killer Cells, Natural (immunology)</term><term>Lactobacillus (isolation & purification)</term><term>Lectins, C-Type (MeSH)</term><term>Male (MeSH)</term><term>Opportunistic Infections (immunology)</term><term>Opportunistic Infections (microbiology)</term><term>Periodontal Diseases (immunology)</term><term>Periodontal Diseases (microbiology)</term><term>Saliva (microbiology)</term><term>Streptococcus (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes CD (métabolisme)</term><term>Antigènes de différenciation des lymphocytes T (métabolisme)</term><term>Caries dentaires (immunologie)</term><term>Caries dentaires (microbiologie)</term><term>Cellules tueuses naturelles (cytologie)</term><term>Cellules tueuses naturelles (immunologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections bactériennes (immunologie)</term><term>Infections bactériennes (microbiologie)</term><term>Infections opportunistes (immunologie)</term><term>Infections opportunistes (microbiologie)</term><term>Lactobacillus (isolement et purification)</term><term>Lectines de type C (MeSH)</term><term>Maladies parodontales (immunologie)</term><term>Maladies parodontales (microbiologie)</term><term>Mâle (MeSH)</term><term>Salive (microbiologie)</term><term>Streptococcus (isolement et purification)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term><term>Antigens, Differentiation, T-Lymphocyte</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules tueuses naturelles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Caries dentaires</term><term>Cellules tueuses naturelles</term><term>Infections bactériennes</term><term>Infections opportunistes</term><term>Maladies parodontales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bacterial Infections</term><term>Dental Caries</term><term>Killer Cells, Natural</term><term>Opportunistic Infections</term><term>Periodontal Diseases</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Lactobacillus</term><term>Streptococcus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Lactobacillus</term><term>Streptococcus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Caries dentaires</term><term>Infections bactériennes</term><term>Infections opportunistes</term><term>Maladies parodontales</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacterial Infections</term><term>Dental Caries</term><term>Opportunistic Infections</term><term>Periodontal Diseases</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term><term>Antigènes de différenciation des lymphocytes T</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Lectins, C-Type</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lectines de type C</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many of the protective immune responses of old people are impaired and this leads to an increased risk of oral bacterial infections. Little is known about the interaction between the systemic immune response on one hand and oral infections and oral diseases on the other. Here, we conducted an epidemiological study of the independent elderly to determine the relationships between activated natural killer (NK) cells and oral bacterial infections: oral diseases such as dental caries and periodontal disease. One hundred independent elderly people aged 77 years old (53 males, 47 females) were examined. Blood samples were drawn, and activated NK cells were evaluated using CD16, CD56, and CD69 monoclonal antibodies with flow cytometry. Bacterial counts for oral streptococci, lactobacillus, and opportunistic pathogens were performed using culture techniques. Oral disease examinations were performed by dentists. A larger percentage of CD69(+)NK cells (CD16(+)CD56(+)) showed significant correlations to the isolation numbers of total streptococci (r=0.409, P<0.01), the species numbers of opportunistic pathogens (r=-0.318, P<0.01), the numbers of decayed teeth (r=-0.223, P<0.05), and the amount of bridge work (r=0.219, P<0.05). A higher proportion of CD69(+)NK cells is associated with the incidence of dental caries and the number of opportunistic pathogens and total streptococci in the oral cavity of the elderly. This suggests that the proportionate number of CD69(+)NK cells may be a useful indicator for oral infection in elderly subjects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19050357</PMID><DateCompleted><Year>2009</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1344-6304</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Japanese journal of infectious diseases</Title><ISOAbbreviation>Jpn J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Role of activated natural killer cells in oral diseases.</ArticleTitle><Pagination><MedlinePgn>469-74</MedlinePgn></Pagination><Abstract><AbstractText>Many of the protective immune responses of old people are impaired and this leads to an increased risk of oral bacterial infections. Little is known about the interaction between the systemic immune response on one hand and oral infections and oral diseases on the other. Here, we conducted an epidemiological study of the independent elderly to determine the relationships between activated natural killer (NK) cells and oral bacterial infections: oral diseases such as dental caries and periodontal disease. One hundred independent elderly people aged 77 years old (53 males, 47 females) were examined. Blood samples were drawn, and activated NK cells were evaluated using CD16, CD56, and CD69 monoclonal antibodies with flow cytometry. Bacterial counts for oral streptococci, lactobacillus, and opportunistic pathogens were performed using culture techniques. Oral disease examinations were performed by dentists. A larger percentage of CD69(+)NK cells (CD16(+)CD56(+)) showed significant correlations to the isolation numbers of total streptococci (r=0.409, P<0.01), the species numbers of opportunistic pathogens (r=-0.318, P<0.01), the numbers of decayed teeth (r=-0.223, P<0.05), and the amount of bridge work (r=0.219, P<0.05). A higher proportion of CD69(+)NK cells is associated with the incidence of dental caries and the number of opportunistic pathogens and total streptococci in the oral cavity of the elderly. This suggests that the proportionate number of CD69(+)NK cells may be a useful indicator for oral infection in elderly subjects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kamoda</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Gerodontology, Tokyo Medical and Dental University, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uematsu</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Yoshihara</LastName><ForeName>Akihiro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Miyazaki</LastName><ForeName>Hideo</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Senpuku</LastName><ForeName>Hidenobu</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Jpn J Infect Dis</MedlineTA><NlmUniqueID>100893704</NlmUniqueID><ISSNLinking>1344-6304</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000945">Antigens, Differentiation, T-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C055855">CD69 antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037181">Lectins, C-Type</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000945" MajorTopicYN="N">Antigens, Differentiation, T-Lymphocyte</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003731" MajorTopicYN="N">Dental Caries</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007778" MajorTopicYN="N">Lactobacillus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D037181" MajorTopicYN="N">Lectins, C-Type</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009894" MajorTopicYN="N">Opportunistic Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013291" MajorTopicYN="N">Streptococcus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>12</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>1</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>12</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19050357</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Miyazaki, Hideo" sort="Miyazaki, Hideo" uniqKey="Miyazaki H" first="Hideo" last="Miyazaki">Hideo Miyazaki</name><name sortKey="Senpuku, Hidenobu" sort="Senpuku, Hidenobu" uniqKey="Senpuku H" first="Hidenobu" last="Senpuku">Hidenobu Senpuku</name><name sortKey="Uematsu, Hiroshi" sort="Uematsu, Hiroshi" uniqKey="Uematsu H" first="Hiroshi" last="Uematsu">Hiroshi Uematsu</name><name sortKey="Yoshihara, Akihiro" sort="Yoshihara, Akihiro" uniqKey="Yoshihara A" first="Akihiro" last="Yoshihara">Akihiro Yoshihara</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Kamoda, Yuji" sort="Kamoda, Yuji" uniqKey="Kamoda Y" first="Yuji" last="Kamoda">Yuji Kamoda</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SuicidDentistV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000382 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000382 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SuicidDentistV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:19050357
|texte= Role of activated natural killer cells in oral diseases.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19050357" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SuicidDentistV1
| This area was generated with Dilib version V0.6.39. |  |